See you most Wednesdays at 0830 on Zoom by clicking here (password 624445). Also have a look at the ICU Trials App on iOS or Android.

Outcomes and Resource Utilization Among Patients Admitted to the Intensive Care Unit Following Acute Exacerbation of Chronic Obstructive Pulmonary Disease (click to download)

  • Coding humans
  • Decisions to die
  • End of life and resources

A Prospective Randomized Controlled Trial on the Efficacy of Noninvasive Ventilation in Severe Acute Asthma (click to download)

  • Retrospective
  • Propensity
  • Codes
  • % go on to ventilation or die same

Blood Culture Results Before and After Antimicrobial Administration in Patients With Severe Manifestations of Sepsis (click to download)

  • Cultures only?
  • Who are you treating?
  • Time to first dose?

Early versus Late Parenteral Nutrition in Critically Ill Adults (click to download).

  • Primary outcome (patient entered?)
  • Short LOS
  • Insulin?
  • How to work with commercial companies?

Prednisolone or Pentoxifylline for Alcoholic Hepatitis (click for download)

Relevance of Lung Ultrasound in the Diagnosis of Acute Respiratory Failure (click for download)

  • Why is 28 days important?
  • Placebo?
  • Read about Julius Fieser
  • Single diagnosis?
  • Experiences?
  • Validation?
  • Now watch this video.

Effect of Intravenous Acetaminophen on Postoperative Hypoxemia After Abdominal Surgery
The FACTOR Randomized Clinical Trial (click for download)

  • Secondary more important that primary
  • Sats and oxygen
  • ASA 1/2 and abdominal surgery

Hydrocortisone and Treatment of Multiple Trauma (click to download)

  • How to define a definition?
  • Patient centred outcomes?
  • What is VAP?

British aneurysm nimodipine trial: Nimodipine in subarachnoid hemorrhage (click for download)

  • Diagnosis?
  • Grade?
  • Vasospasm?
  • Now read this

REDCAP (click for download)

  • Blind leading the blind?
  • Words are not always free.
  • Cap or no cap?

SUP-ICU (click for download)

  • Drink vommit?
  • NNT 60 to prevent treatment with PPI?
  • High / low risk

Remdesivir for the Treatment of Covid-19 — Final Report (click for download)

  • 10 days but not 10 days
  • The Tamiflu of COVID?
  • Primary changes

PR decision-making conversations in the UK: an integrative review (click here for document)

  • UK English (1.5/7.5 billion)
  • McMillian?
  • ECMO
  • Nurses before and after

Standard versus Accelerated Initiation of Renal Replacement Therapy (click here to download)

Think about:

  • Who are the three sisters?
  • Why economics matters.
  • Are these like our patients?

Conservative Oxygen Therapy during Mechanical Ventilation in the ICU (click to download)

Thank about:

  • Low vs low?
  • MEGAROX trial
  • Future trial direction?

DAILY INTERRUPTION OF SEDATIVE INFUSIONS IN CRITICALLY ILL PATIENTS UNDERGOING MECHANICAL VENTILATION (click to read original paper)

Think about:

  • Two countries divided by a common language
  • Protocol violations
  • Blinding

PROSEVA (click to read original paper)

  • High volume = high benefit?
  • Too good to be true?
  • Self-selected groups?

Now have a read of the excellent Bottom Line review on the trial.

CITRIS-AL (click to read original paper)

  • Vic C and the start of evidence
  • Primary end points are political
  • Syndrome + syndrome

FRAIL-FIT (click to read original paper)

  • Invisible women?
  • Cause vs effect
  • Binary cut off using a hover.

SMART (click to read the original paper)

  • Why is everything sometimes less?
  • The blind following the blind?
  • Why are subgroups sub-optimal?

Now read https://emcrit.org/pulmcrit/smart/ and https://www.thebottomline.org.uk/summaries/icm/smart/.


RESCUE-ICP (click to read the original paper)

  • Why is timing is everything (this vs DECRA)?
  • What is the good life?