See you most Wednesdays at 0830 on Zoom by clicking here (password 624445). Also have a look at the ICU Trials App on iOS or Android.
SAFE study (click to download)
- 1832 -> Having inserted a tube into the basilic vein, cautiously, anxiously, I watched the effect; ounce after ounce was injected, but no visible change was produced. Still persevering, I thought she began to breath less laboriously; soon the sharpened features and sunken eye and fallen jaw, pale and cold, bearing the manifest impress of death’s signet, began to glow with returning animation; the pulse which had long ceased, returned to the wrist, at first small and quick, by degrees it became more and more distinct, fuller, slower and firmer, and in a short space of half an hour, when six pints had been injected, she expressed in a firm voice that she was free from all uneasiness, actually became jocular, and fancied all she needed was a little sleep; her extremities were warm, and every feature bore the aspect of comfort and health.
- Rise of ANZICS
- Subgroups (sepsis/TBI)
- Mechanical Butane Ignition Vaporizer, Joseph Robinson
- Public health examples
- Death off case reports
Acute mesenteric ischemia: guidelines of the World Society of Emergency Surgery (click to download)
- Hammers and nails.
- Anticoagulation.
- Chicken or egg.
Electrolyte disorders during the initiation of nutrition therapy in the ICU (click to download)
- DB and NEJM?
- Early feeding?
- PO4
- Coding humans
- Decisions to die
- End of life and resources
- Retrospective
- Propensity
- Codes
- % go on to ventilation or die same
- Cultures only?
- Who are you treating?
- Time to first dose?
Early versus Late Parenteral Nutrition in Critically Ill Adults (click to download).
- Primary outcome (patient entered?)
- Short LOS
- Insulin?
- How to work with commercial companies?
Prednisolone or Pentoxifylline for Alcoholic Hepatitis (click for download)
Relevance of Lung Ultrasound in the Diagnosis of Acute Respiratory Failure (click for download)
- Why is 28 days important?
- Placebo?
- Read about Julius Fieser
- Single diagnosis?
- Experiences?
- Validation?
- Now watch this video.
- Secondary more important that primary
- Sats and oxygen
- ASA 1/2 and abdominal surgery
Hydrocortisone and Treatment of Multiple Trauma (click to download)
- How to define a definition?
- Patient centred outcomes?
- What is VAP?
British aneurysm nimodipine trial: Nimodipine in subarachnoid hemorrhage (click for download)
- Diagnosis?
- Grade?
- Vasospasm?
- Now read this
- Blind leading the blind?
- Words are not always free.
- Cap or no cap?
- Drink vommit?
- NNT 60 to prevent treatment with PPI?
- High / low risk
Remdesivir for the Treatment of Covid-19 — Final Report (click for download)
- 10 days but not 10 days
- The Tamiflu of COVID?
- Primary changes
PR decision-making conversations in the UK: an integrative review (click here for document)
- UK English (1.5/7.5 billion)
- McMillian?
- ECMO
- Nurses before and after
Standard versus Accelerated Initiation of Renal Replacement Therapy (click here to download)
Think about:
- Who are the three sisters?
- Why economics matters.
- Are these like our patients?
Conservative Oxygen Therapy during Mechanical Ventilation in the ICU (click to download)
Thank about:
- Low vs low?
- MEGAROX trial
- Future trial direction?
Think about:
- Two countries divided by a common language
- Protocol violations
- Blinding
PROSEVA (click to read original paper)
- High volume = high benefit?
- Too good to be true?
- Self-selected groups?
Now have a read of the excellent Bottom Line review on the trial.
CITRIS-AL (click to read original paper)
- Vic C and the start of evidence
- Primary end points are political
- Syndrome + syndrome
FRAIL-FIT (click to read original paper)
- Invisible women?
- Cause vs effect
- Binary cut off using a hover.
SMART (click to read the original paper)
- Why is everything sometimes less?
- The blind following the blind?
- Why are subgroups sub-optimal?
Now read https://emcrit.org/pulmcrit/smart/ and https://www.thebottomline.org.uk/summaries/icm/smart/.
RESCUE-ICP (click to read the original paper)
- Why is timing is everything (this vs DECRA)?
- What is the good life?
- Intention to (not) treat?
- Now go and read these two: https://emcrit.org/emnerd/cc-nerd-the-case-of-the-decompressed-cranium/ and https://www.thebottomline.org.uk/summaries/icm/rescue-icp/
- Then watch the amazing BBC documentary “Between Life and Death” that may make you reconsider any firm beliefs you have about what is or is not acceptable to you.