See you most Wednesdays at 0830 on Zoom by clicking here (password 624445). Also have a look at the ICU Trials App on iOS or Android.

Remdesivir for the Treatment of Covid-19 — Final Report (click for download)

  • 10 days but not 10 days
  • The Tamiflu of COVID?
  • Primary changes

PR decision-making conversations in the UK: an integrative review (click here for document)

  • UK English (1.5/7.5 billion)
  • McMillian?
  • ECMO
  • Nurses before and after

Standard versus Accelerated Initiation of Renal Replacement Therapy (click here to download)

Think about:

  • Who are the three sisters?
  • Why economics matters.
  • Are these like our patients?

Conservative Oxygen Therapy during Mechanical Ventilation in the ICU (click to download)

Thank about:

  • Low vs low?
  • MEGAROX trial
  • Future trial direction?

DAILY INTERRUPTION OF SEDATIVE INFUSIONS IN CRITICALLY ILL PATIENTS UNDERGOING MECHANICAL VENTILATION (click to read original paper)

Think about:

  • Two countries divided by a common language
  • Protocol violations
  • Blinding

PROSEVA (click to read original paper)

  • High volume = high benefit?
  • Too good to be true?
  • Self-selected groups?

Now have a read of the excellent Bottom Line review on the trial.

CITRIS-AL (click to read original paper)

  • Vic C and the start of evidence
  • Primary end points are political
  • Syndrome + syndrome

FRAIL-FIT (click to read original paper)

  • Invisible women?
  • Cause vs effect
  • Binary cut off using a hover.

SMART (click to read the original paper)

  • Why is everything sometimes less?
  • The blind following the blind?
  • Why are subgroups sub-optimal?

Now read https://emcrit.org/pulmcrit/smart/ and https://www.thebottomline.org.uk/summaries/icm/smart/.

RESCUE-ICP (click to read the original paper)

  • Why is timing is everything (this vs DECRA)?
  • What is the good life?